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Bortezomib CAS 179324-69-7 for Cancer Treatment
Product Name:
Bortezomib CAS 179324-69-7 for Cancer Treatment
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Product Description:

Bortezomib CAS 179324-69-7 for Cancer Treatment
Product Name: Bortezomib
Synonyms: Boronic acid, B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)aMino]propyl]aMino]bu;MG-341 PS-341;BortezoMib Base;BortezoMib-D8;bortezoMib(other);MLM341;BortezoMib R;VELCADE(BORTEZOMIB)
CAS: 179324-69-7
MF: C19H25BN4O4
MW: 384.24
EINECS: 605-854-3
Melting point 122-124°C
density 1.214
RTECS ED7771666
storage temp. Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.
pka 9.66±0.43(Predicted)
Stability: Hygroscopic and Moisture Sensitive
Description Bortezomib, a modified dipeptidyl boronic acid, is a therapeutic proteasome inhibitors used for the treatment of cancers. It is indicated for the treatment of relapsed multiple myeloma and mantle cell lymphoma. It is capable of inhibiting the mammalian 26S proteasome, which is important in regulating the intracellular concentration of specific proteins to maintain homeostasis within cells. The disruption of 26S proteasome function disrupts normal cellular homeostasis, leading to cytotoxic effect on various kinds of cancer cells.