Hubei Honest Biochemical Co., Ltd.

Clotrimazole

Product Name: Clotrimazole

Synonyms: G imazalil;Tartaric acid Tiamulin;Clotrimazole, >=99%;Levobupivacaine Hydrochloride Injection;Perindopril Tables[ACERTIL(R;chlorophyll、chlorophyl;Clotrimazole impurity;(2-Chlorophenyl)diphenyl-1-imidazolylmethane

CAS: 23593-75-1

MF: C22H17ClN2

MW: 344.84

EINECS: 245-764-8 

Chemical Properties It is white powder or colorless crystalline powder. It has a melting point of 147-149 ℃. It is soluble in ethanol, acetone, and chloroform, but almost insoluble in water. It is odorless, tasteless and subject to rapid decomposition in an acid solution. Clotrimazole hydrochloride has a m.p. of 159 ℃.

Production method It can be obtained from o-benzoic acid via esterification, addition, hydrolysis, chlorination, and condensation. It may also be obtained by chlorination of o-chlorotoluene into o-chloro benzotrichloride, which, in the presence of aluminum chloride, has condensation reaction with benzene to generate diphenyl-(2-chlorophenyl) methyl chloride, which finally has condensation reaction with imidazole to obtain clotrimazole.