Hubei Honest Biochemical Co., Ltd.

English name: Celecoxib

English Name: Celebrex

CAS: 169590-42-5

Formula: C17H14F3N3O2S

MW: 381.3722

Molecular structure:

 

Celebrex Anti Inflammatory Steroids 99% Purity 169590-42-5 for Treatment Arthritis API Celecoxib

 

Density: 1.43g / cm3

Melting point: 157-159 ℃

Boiling point: 529 ° C at 760 mmHg

Flash Point: 273.7 ° C

Vapor Pressure: 2.81E-11mmHg at 25 ° C

Action for the treatment of arthritis, has anti-inflammatory analgesic, relieve osteoarthritis and rheumatoid arthritis signs and symptoms: Usage

Assay:99%

Appearance: White or almost white crystalline powder

 

2.  Descriptions:

 

Celecoxib is a COX-2 selective nonsteroidal anti-inflammatory drug. It is used to treat the signs and symptoms of osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute pain in adults, painful menstruation, and juvenile rheumatoid arthritis in patients two years or older.

Side effects include a 37% increase in incidence of major vascular events, which include nonfatal myocardial infarction, nonfatal stroke, or death from a blood vessel-related cause.Additionally, an 81% increase in incidence of upper gastrointestinal complications occurs, which include perforations, obstructions, or gastrointestinal bleeding as in all NSAIDs.

 

3.  Applications:

 

Celecoxib is used for osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, ankylosing spondylitis, and to reduce the number of colon and rectal polyps in people with familial adenomatous polyposis. It may also be used in children with juvenile rheumatoid arthritis who are older than two years of age and weigh more than 10 kg (22 lb).

 

For postoperative pain, it is more or less equal to ibuprofen. For pain relief, it is similar to paracetamol(acetaminophen). And in osteoarthritis acetaminophen is the first line treatment for OA.

 

It was originally intended to relieve pain while minimizing the gastrointestinal adverse effects seen with conventional NSAIDs. In practice, its primary use is in people who need regular and long-term pain relief; probably, no advantage exists to using celecoxib for short-term or acute pain relief over conventional NSAIDs, except in the situation where nonselective NSAIDs or aspirin cause cutaneous reactions (urticaria or "hives").

Mental illness

Tentative evidence indicates its use in treating a number of psychiatric disorders, including major depression, bipolar disorder, and schizophrenia.

Familial adenomatous polyposis

It has been used to reduce colon and rectal polyps in people with familial adenomatous polyposis, but it is not known if it decreases rates of cancer, so it is not a good choice for this reason.