Hubei Honest Biochemical Co., Ltd.

What is ANDARINE?

Andarine is a selective non-steroidal androgen receptor (AR) agonist with Ki of 4 nM, and it is tissue selective for the metabolic organ. 

Andarine has an effective metabolic activity, and stimulates the growth of the prostate, seminal vesicle, and levator ani, with ED50 is 0.43 mg/day, 0.55 mg/day, and 0.14 mg/day respectively. This effect is dose dependent. In addition, Andarine acts on FSH, which does not affect some physiological changes caused by castration, and at a dose of 0.5 mg or more per day, partially inhibiting LH production. Andarine was administered to dog intravenously at 0.1, 1, 3, and 10 mg/kg doses, then the total body clearance (CL) decreased from 7.4 mL/min/kg to 3.1 mL/min/kg, the steady-state volume (Vss) was 1.39 L/kg and the half-life was 229 minutes. In addition, Andarine was 10 mg/kg, 1 mg/kg and 0.1 mg/kg, with oral bioavailability of 38%, 62% and 91% respectively. Andarine has tissue selective pharmacological activity and is well treated with 0.5 mg/day concentration, significantly reducing prostate weight to 79.4%.

Andarine (S-4) is one of my favorite SARMS in the market. Like all SARMs, Andarine is a selective androgen receptor modulator. It’s full name is S-40503, and it quickly became known as S-4, while stronger versions have been dubbed Andarine. Andarine was developed by the Japanese pharmaceutical company, Kaken Pharmaceuticals, and it was aimed at treating osteoporosis. In our world, andarine has been picked up by bodybuilders and gym rats over the last several years as a way to take their gains to the next level; as a result, it has been banned by tested contests and organized sports. Although some say that andarine is probably the most comparable to steroids such as winstrol or anavar as far as the aesthetic effects on one’s physique, it’s not a steroid.

How it works?

Andarine binds incredibly well to the androgen receptors of bone and muscle. While it doesn’t tend to impress in terms of building pounds upon pounds of muscle like trenbolone will, it has amazing effects on fat loss. Why? Andarine is the least anabolic, yet most androgenic of the SARMS. When androgenic hormones or sarms attach to the androgen receptors in your adipose tissue or fat (yes we have androgen receptors in our fat too) they trigger fat oxidation.

This SARM is selective and shows no noticeable prostate activity. Andarine proved to be poor at building muscle tissue at lower doses, but it did, in fact, build lean hard muscle tissue at higher doses. These tissue gains have often been compared to that of winstrol or anavar, but, of course, without the associated androgenic side effects. Andarine is especially outstanding at strengthening, preserving and even building bone mass.

Andarine’s exceptional ability to help oxidize fat and keep your body from going catabolic while on a low calorie diet is its specialty. It will provide a hard, dry, lean look and increase vascularity. It provides notable strength and endurance even while in caloric deficit, and, at higher doses, it can even add hard muscle to your frame. Any other SARM stacks wonderfully with andarine, and the results will be compounded due to their synergistic effects. A stack of Andarine and ostarine (mk-2866), for example, would provide results arguably comparable to a stack of testosterone and winstrol. Again, SARMS are not steroids, and they provide less androgenic and anabolic effects as actual steroids, but the effects are very similar. Andarine can also be used by itself and provide fantastic results.

Dosages and Suggestion

Andarine is recommended at doses of 50-75mg a day, and has even been tolerated at 100mg, although it is highly recommended to start low and gradually increase dosage to keeps side effects minimal. It has a half-life of 4 hours, so I recommend you dose andarine (s4) at least twice a day, and probably even more ideally 3 timers per day. Optimum length of Andarine cycles are said to be up to 8 weeks long and is not hepatotoxic, so unlike oral steroids and comparable drugs, longer cycles do not cause danger to the liver.