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Hubei Honest Biochemical Co., Ltd. |
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Levothyroxine Sodium
Synonyms:Sodium (s)-2-Amino-3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]Propionate Pentahydrate;
(s)-2-Amino-3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]Propionic Acid Sodium Salt Pentahydrate;3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]-l-Alanine Sodium Salt Pentahydrate;3-[4-(4-Hydroxy-3,5-Diiodophenoxy)-3,5-Diiodophenyl]-l-Alanine Pentahydrate;
l-Thyroxine Sodium Salt Pentahydrate;l-Thyroxine Sodium Pentahydrate
CAS:55-03-8
MF: C15H20I4NNaO9
MW:888.93
EINECS: 200-221-4
Chemical Properties:White Solid
Melting point: 207-210 (dec.)(lit.)
Solubility: cell culture medium: 0.1 mg/mL
Usage:One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
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Item |
Specification |
Result |
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Appearance |
An odorless, almost white or buff colored powder |
pass |
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Solubility |
1,Very slightly soluble in water |
pass |
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2,slightly soluble in alcohol |
pass |
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3,practically insoluble in most other organic solvents |
pass |
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4,disolves in diluted aqueous sodium hydroxide solutions |
Pass |
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Identification |
a) Heat about 50 mg with a few drops of sulfuric acid in a porcelain crucible: violet vapors of iodine are evolved. |
pass |
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b)The retention time of the major peak is confirm to the RS |
pass |
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Loss on Drying |
Not more than 4.0% |
0.46% |
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[a]20/D |
+18 ~ +22o |
+20.9o |
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Assay(HPLC) |
Not less than 95.0% |
99.18% |
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Levothyroxine sodium |
Not more than 5.0% |
0.68% |
